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The proposed mechanism centers on modulation of the nitric oxide system: BPC-157 counteracts L-NAME-induced eNOS blockade in rat models and supports vascular sprouting through VEGFR2 internalization (Hsieh et al., J Mol Med , 2017)

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The perpendicular diameters of the tumours were measured three times weekly using standard calipers and tumour volumes were calculated using the formula: 0.5 D d 2 , where D and d were the longest and shortest perpendicular diameters, respectively